ACADEMIA NACIONAL DE MEDICINA DE COLOMBIA

Brain and Microgravity

Visto: 1736

The central nervous system risks may include: altered cognitive function, reduced motor function, and behavioral changes, all of which may affect performance and human health. Late CNS risks may include neurological disorders such as Alzheimer’s disease (AD), dementia and premature aging.

Acute CNS risks include changes in cognition, motor function, behavior, and mood, which may affect performance and human health. Specific examples of human behaviors and cognitive function of interest that may be affected by space flight include short-term memory, learning, spatial orientation, motor function, emotion recognition, risk decision making, vigilance, reaction time, processing speed, circadian regulation, fatigue, and neuropsychological changes.

Consult reports and evidence of human research of NASA "Human Research Roadmap": https://humanresearchroadmap.nasa.gov/explore/

Conflicts of interests

None stated by the authors

Financing

None stated by the authors.

REFERENCES

  1. The Brain in Space: A Teacher’s Guide With Activities for Neuroscience, EG-1998-03-118-HQ, Education Standards, Grades 5–8, 9–12.
  2. Gregory A. Nelson; Evidence Report: Risk of Acute and Late Central Nervous System Effects from Radiation Exposure; Human Research Program Space Radiation Program Element- Approved for Public Release: April 6, 2016- National Aeronautics and Space Administration, Lyndon B. Johnson Space Center- Houston, Texas.
  3. Tseng BP, Giedzinski E, Izadi A et al (2014) Functional consequences of radiation-induced oxidative stress in cultured neural stem cells and the brain exposed to charged particle irradiation. Antioxid Redox Signal 20:1410-1422.
  4.  Tseng BP, Lan ML, Tran KK, Acharya MM, Giedzinski E, Limoli CL (2013) Characterizing low dose and dose rate effects in rodent and human neural stem cells exposed to proton and gamma irradiation Redox Biol 19(1):153-162.
  5. Vazquez ME, Kirk E (2000) In vitro neurotoxic effects of 1 GeV/n iron particles assessed in retinal explants. Adv Space Res 25:2041-2049.
  6. Wong CS, Van der Kogel AJ (2004) Mechanisms of radiation injury to the central nervous system: implications for neuroprotection. Mol Interv 4:273-284.
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