ACADEMIA NACIONAL DE MEDICINA DE COLOMBIA

FEVER AND INFLAMMATION / PROSTAGLANDIN E2.

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PROSTAGLANDIN E2 AND FEVER:
Fever is a common symptom of infectious and inflammatory disease. It is well established that prostaglandin E2 is the final mediator of fever, which by binding to its EP3 receptor subtype in the preoptic hypothalamus initiates thermogenesis (1).
Fever is a cardinal response to infection that has been conserved in warm and cold-blooded vertebrates for over 600 million years of evolution (2). The fever response is a hallmark of infection and inflammatory disease and has been shaped through hundreds of millions of years of natural selection (3). 

Artículo escrito por el Grupo de Investigación en Salud (GIS), de la Facultad de Ciencias de la Salud, Universidad del Cauca. (Documento completo adjunto)

 

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